참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester | HCID 59401123 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | (R)-(4-fluoro-phenylamino)-phenyl-acetic acid | HCID 7006576 | 87% |
반응 단계
To a solution of (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (I252) (510 mg, 1.97 mmol) in dioxane (10 mL), is added 12N HCl (10 mL) and the mixture is heated at 70° C. for 12 hours. The organic solvent is evaporated, the mixture is cooled to 0° C. and the resulting solid is collected by filtration to obtain intermediate I255 as a brownish solid (420 mg, 87% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08835682B2 |
|---|
| 출처 데이터셋 | uspto-grants-2014_09 |
|---|
| ORD ID | ord-ca0cfb9e27b8439b9066a740e8f09515 |
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| 출처 메모 | uspto-grants-2014_09 |
|---|
