反应详情

温度

70 °C

To a solution of (R)-(4-fluoro-phenylamino)-phenyl-acetic acid methyl ester (I252) (510 mg, 1.97 mmol) in dioxane (10 mL), is added 12N HCl (10 mL) and the mixture is heated at 70° C. for 12 hours. The organic solvent is evaporated, the mixture is cooled to 0° C. and the resulting solid is collected by filtration to obtain intermediate I255 as a brownish solid (420 mg, 87% yield).

1. customThe organic solvent is evaporated
2. temperaturethe mixture is cooled to 0° C.
3. filtrationthe resulting solid is collected by filtration
4. customto obtain intermediate