反应详情

To a solution of methyl 2-(2-fluorophenyl)acetate (1.0 g, 5.95 mmol) in CCl4 (15 mL), are added N-bromo succinimide (1.06 g, 5.95 mmol) and 48% hydrogen bromide (33 uL, 0.30 mmol) and the reaction is refluxed for 15 hours. Reaction is diluted with DCM and washed with Na2CO3 and water. The organic phase is dried over Na2SO4, filtered and evaporated under vacuum to afford intermediate I261 as a dark brown oil (1.47 g, quantitative yield).

1. temperaturethe reaction is refluxed for 15 hours
2. customReaction
3. washwashed with Na2CO3 and water
4. dry with materialThe organic phase is dried over Na2SO4
5. filtrationfiltered
6. customevaporated under vacuum