N-(2-Amino-5-chloro-phenyl)-5-bromo-2-fluoro-benzamide → HCID 178505483, compound

HRID 77080Notes

Reaction equation

HRID 77080 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[NH:9][C:10](=O)[C:11]1[CH:16]=[C:15]([Br:17])[CH:14]=[CH:13][C:12]=1[F:18]>C(O)(=O)C>[Br:17][C:15]1[CH:14]=[CH:13][C:12]([F:18])=[C:11]([C:10]2[NH:1][C:2]3[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=3[N:9]=2)[CH:16]=1

Participants

3

Reactant 1

HCID 24699699N-(2-Amino-5-chloro-phenyl)-5-bromo-2-fluoro-benzamide

Product 1

HCID 178505483HCID 178505483, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
85 °C

Procedure

Method 7—Step b A mixture of N-(2-Amino-5-chloro-phenyl)-5-bromo-2-fluoro-benzamide (1.60 g, 4.67 mmol) in acetic acid (10 mL) was heated at 85° C. overnight. Solvent was removed under reduced pressure and the solid obtained was washed with dichloromethane and dried to obtain 1.40 g of the title compound (93%).

Workup

  1. customSolvent was removed under reduced pressure
  2. customthe solid obtained
  3. washwas washed with dichloromethane
  4. customdried

Sources & evidence

ORD record
ord-3c482643c6b54f34b682f4dfcc5ca817
Source dataset
uspto-grants-2014_09
Patent number
US08835648B2

Reaction notes

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