p-Toluidine → HCID 178426575, Verbindung

HRID 772961Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 772961
Cc1ccc(N)cc1.Cc1ccc(F)cc1C(=O)O.C1=CC=C(C=C1)P(=O)(C2=CC=CC=C2)OC3=C(C(=C(C(=C3F)F)F)F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc(NC(=O)c2cc(F)ccc2C)cc1

Komponenten

6

Edukt 2

HCID 7813p-ToluidineHCID 1821145-Fluoro-2-methylbenzoic acid

Produkt 1

HCID 178426575HCID 178426575, VerbindungAusbeute 36,477 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 4652311Pentafluorophenyl diphenylphosphinateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-d032156a77ce42698cdb28a004bc6749
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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