Hydrochloric Acid → HCID 86653280, compound

HRID 77334Notes

Reaction equation

HRID 77334 reaction equation
C([NH:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([S:15]([N:18]([CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH:19]([CH:24]([CH3:26])[CH3:25])[C:20]([NH:22][OH:23])=[O:21])(=[O:17])=[O:16])=[CH:12]2)=[CH:7][CH:6]=1)(=O)C.Cl>CO>[NH2:4][C:5]1[CH:14]=[C:13]2[C:8]([CH:9]=[CH:10][C:11]([S:15]([N:18]([CH2:27][CH2:28][CH:29]([CH3:31])[CH3:30])[CH:19]([CH:24]([CH3:25])[CH3:26])[C:20]([NH:22][OH:23])=[O:21])(=[O:17])=[O:16])=[CH:12]2)=[CH:7][CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 866532812-[(7-Acetylamino-naphthalene-2-sulfonyl)-(3-methyl-butyl)-amino]-N-hydroxy-3-methyl-butyramide

Product 1

HCID 86653280HCID 86653280, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2-[(7-Acetylamino-naphthalene-2-sulfonyl)-(3-methyl-butyl)-amino]-N-hydroxy-3-methyl-butyramide (100 mg, 0.22 mmol) (example 61), 3 N hydrochloric acid (2 mL) and methanol (5 mL) are combined and stirred at reflux for 4 hours. The mixture is stirred at room for 60 hours. The solvent is partially removed in vacuo and a red precipitate forms. This precipitate is collected by filtration and air dried. LCMS (m/z): 408.2 (M+1), 406.3 (M−1).

Workup

  1. temperatureat reflux for 4 hours
  2. stirringThe mixture is stirred at room for 60 hours
  3. customThe solvent is partially removed in vacuo
  4. filtrationThis precipitate is collected by filtration and air
  5. customdried

Sources & evidence

ORD record
ord-4b45c0cb661e443fac8f97a700e44479
Source dataset
uspto-grants-2014_09
Patent number
US08841291B2

Reaction notes

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