反应详情

2-[(7-Acetylamino-naphthalene-2-sulfonyl)-(3-methyl-butyl)-amino]-N-hydroxy-3-methyl-butyramide (100 mg, 0.22 mmol) (example 61), 3 N hydrochloric acid (2 mL) and methanol (5 mL) are combined and stirred at reflux for 4 hours. The mixture is stirred at room for 60 hours. The solvent is partially removed in vacuo and a red precipitate forms. This precipitate is collected by filtration and air dried. LCMS (m/z): 408.2 (M+1), 406.3 (M−1).

1. temperatureat reflux for 4 hours
2. stirringThe mixture is stirred at room for 60 hours
3. customThe solvent is partially removed in vacuo
4. filtrationThis precipitate is collected by filtration and air
5. customdried