Thionyl Chloride → 5-Fluoro-2-nitrobenzoyl chloride

Participants

Reaction Steps

5-Fluoro-2-nitrobenzoic acid (15.0 g, 81.0 mmol) was refluxed in thionyl chloride (67.5 g, 567 mmol) for 2.5 hours. The reaction mixture was allowed to cool to room temperature and the excess thionyl chloride removed under reduced pressure, to afford 5-fluoro-2-nitrobenzoyl chloride (16.5 g, 81.0 mmol).

Provenance & Evidence