反应详情

To a solution of iodomethane (0.18 g, 1.3 mmol) in THF (12 mL) was added 6-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-2-(3-chlorophenyl)-3-methylquinazolin-4(3H)-one (Example 2AL) (0.5 g, 1.3 mmol) and reaction stirred for two days. The resultant precipitate was collected via filtration, triturated with minimum amount of methanol and dried to afford 4-(2-(3-chlorophenyl)-3-methyl-4-oxo-3,4-dihydroquinazolin-6-yl)-1-methyl-4-aza-1-azoniabicyclo[3.2.2]nonane iodide (0.44 g, 0.82 mmol).

1. filtrationThe resultant precipitate was collected via filtration
2. customtriturated with minimum amount of methanol
3. customdried