反应详情

To a solution of N-(3-chloro-4-(difluoromethoxy)phenyl)-5-(2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)vinyl)pyrimidin-2-amine (0.10 g, 0.201 mmol) in ethyl acetate (10 mL) was added Pd/C (0.214 g, 2.008 mmol). The reaction mixture was stirred at room temperature under hydrogen for 12 h. The reaction mixture was filtered through celite and the filtrate was concentrated to give N-(3-chloro-4-(difluoromethoxy)phenyl)-5-(2-(1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-5-yl)ethyl)pyrimidin-2-amine (0.16 g, 80%). LCMS (ES-API), RT: 2.21 m/z 500.2 (M+H).

1. filtrationThe reaction mixture was filtered through celite
2. concentrationthe filtrate was concentrated