HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → Trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | (S)-{1-[(4-Chloro-benzylcarbamoyl)-methyl]-piperidin-3-yl}-carbamic acid tert-butyl ester | HCID 86713541 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Trifluoroacetate | HCID 84468 | — |
| Product | (S)-2-(3-Amino-piperidin-1-yl)-N-(4-chloro-benzyl)-acetamide | HCID 86713540 | — |
Reaction Steps
A solution of 60 mg (S)-{1-[(4-Chloro-benzylcarbamoyl)-methyl]-piperidin-3-yl}-carbamic acid tert-butyl ester (intermediate 7.7A) in 5 ml dichloromethane is treated with 50 μl TFA and stirred overnight at room temperature. The mixture is evaporated to yield the title compound as a trifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841309B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-afb87b145a4448239ccec02efe33df7c |
| Source note | uspto-grants-2014_09 |