反应详情

N-1-Aza-bicyclo[2.2.2]oct-3-yl-N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidine (Intermediate 4, 30 mg, 0.089 mmol) and benzyl bromide (Acros, 17 mg, 0.097 mmol) are stirred for 4 h at 70° C. in acetonitrile (2 mL). To the suspension is added diethyl ether (2 mL), the solid collected by filtration, washed with diethyl ether and dried under vacuum to yield the title compound (26 mg).

1. filtrationthe solid collected by filtration
2. washwashed with diethyl ether
3. customdried under vacuum