Chloride → HCID 178479360, compound

HRID 77521Notes

Reaction equation

C([O:5][C:6]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:39])[CH2:15][N+:16]23[CH2:23][CH2:22][CH:19]([CH2:20][CH2:21]2)[C@H:18]([NH:24][C:25]([NH2:38])=[N:26][C:27]([C:29]2[C:34]([NH2:35])=[N:33][C:32]([NH2:36])=[C:31]([Cl:37])[N:30]=2)=[O:28])[CH2:17]3)[CH2:10][CH2:9]1)=[O:7])(C)(C)C.[Cl-:40]>>[ClH:37].[Cl-:40].[C:6]([CH:8]1[CH2:13][CH2:12][N:11]([C:14](=[O:39])[CH2:15][N+:16]23[CH2:23][CH2:22][CH:19]([CH2:20][CH2:21]2)[C@H:18]([NH:24][C:25]([NH2:38])=[N:26][C:27]([C:29]2[C:34]([NH2:35])=[N:33][C:32]([NH2:36])=[C:31]([Cl:37])[N:30]=2)=[O:28])[CH2:17]3)[CH2:10][CH2:9]1)([OH:7])=[O:5]

Participants

Reactant 2

HCID 312Chloride2×

HCID 178450744HCID 178450744, compound

Product 1

HCID 178479360HCID 178479360, compound

Procedure

Starting from 120 mg (0.20 mmol) of (S)-1-[2-(4-tert-butoxycarbonyl-piperidin-1-yl)-2-oxo-ethyl]-3-[N′-(3,5-diamino-6-chloro-pyrazine-2-carbonyl)-guanidino]-1-azonia-bicyclo[2.2.2]octane; chloride (Intermediate 67).

Sources & evidence

ORD record: ord-e9ce4a77e59d4fdbb64e2d737c26bf04
Source dataset: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08841309B2

Reaction notes

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