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4-Amino-N-methylbenzenemethanesulfonamide → C-{4-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-N-methyl-methanesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Amino-N-methylbenzenemethanesulfonamide | HCID 2778131 | — |
| 反応物 | 2-Chloro-4-(2-methoxyphenyl)pyrimidine | HCID 24901882 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | C-{4-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-N-methyl-methanesulfonamide | HCID 59396139 | — |
反応手順
A solution of 2-chloro-4-(2-methoxy-phenyl)-pyrimidine (0.883 g, 0.004 mol), and C-(4-amino-phenyl)-N-methyl-methanesulfonamide (0.801 g, 0.004 mol) (Macor, John E.; Blank et al., Tetrahedron Letters (1992), 33(52), 8011-14) in DMF is stirred in DMF (12 ml) for 2 hours at 80° C. (TLC control). The solvent was removed under reduced pressure to give C-{4-[4-(2-methoxy-phenyl)-pyrimidin-2-ylamino]-phenyl}-N-methyl-methanesulfonamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08841315B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-addda20ab1724d6386f965e0cd30699d |
| 出典メモ | uspto-grants-2014_09 |