反应详情

温度

50 °C

A solution of 1-(3-bromophenyl)-2-(diallylamino)ethanone (60 g, 204.7 mmol) in ethanol (720 mL) and pyridine (24.8 mL, 307 mmol) is stirred 15 minutes at 22° C. Hydroxylamine hydrochloride (17 g, 246 mmol) is added in portions to the solution over 1 hour. The reaction is warmed to 50° C. for 2 hours and then heated to 70° C. for 16 hours. The solvent is evaporated and the residue partitioned in water (300 mL) and methyl tert-butyl ether (300 mL). The organic layer is separated and washed with water (100 mL, 2×) and brine (100 mL). The organic layer is dried over sodium sulfate, filtered, and evaporated to dryness to give the title compound (75.5 g, 79%). ES/MS (m/e): 309 (M+1).

1. temperatureheated to 70° C. for 16 hours
2. customThe solvent is evaporated
3. customthe residue partitioned in water (300 mL)
4. customThe organic layer is separated
5. washwashed with water (100 mL, 2×) and brine (100 mL)
6. dry with materialThe organic layer is dried over sodium sulfate
7. filtrationfiltered
8. customevaporated to dryness