反应详情

To a solution of 5-(1,3-benzoxazol-2-yl)-2-methoxy benzonitrile (270 mg, 1.1 mmol) in CH2Cl2 (5 mL) at 0° C., was added BBr3 (1.0M solution in CH2Cl2, 430 μL, 4.4 mmol) dropwise. The reaction was stirred at it for 4 h. EtOAc (150 mL) was added, as well as H2O (30 mL). The organic layer was washed with brine (2×20 mL), dried (MgSO4), concentrated and the crude product was recrystallized in EtOAc to afford 5-(1,3-benzoxazol-2-yl)-2-hydroxy benzonitrile. MS (ESI) 237 (M+H)+.

1. washThe organic layer was washed with brine (2×20 mL)
2. dry with materialdried (MgSO4)
3. concentrationconcentrated
4. customthe crude product was recrystallized in EtOAc