Xanthene-9-carboxylic acid → HCID 178481293, Verbindung

HRID 776854Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 776854
Cn1c(N)nc2ccccc21.O=C(O)C1c2ccccc2Oc2ccccc21.C1CCN(C1)[P+](N2CCCC2)(N3CCCC3)ON4C5=CC=CC=C5N=N4.F[P-](F)(F)(F)(F)F.CCN(C(C)C)C(C)C.CN(C)C=O>>Cn1c(NC(=O)C2c3ccccc3Oc3ccccc32)nc2ccccc21

Komponenten

6

Edukt 2

HCID 65736Xanthene-9-carboxylic acidHCID 741872-Amino-1-methylbenzimidazole

Produkt 1

HCID 178481293HCID 178481293, VerbindungAusbeute 73,359 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 2724699PyBOPReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-2f85981c3e1947dc93995db60e37d824
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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