反应详情

温度

65 °C

To ethanol (20 mL) were added concentrated sulfuric acid (10 mL) and 2-amino-6-chloro-nicotinic acid (6.3 g, 27 mmol, purity: 75%) described in Manufacturing Example 26-1-1 on an ice bath, which was stirred overnight at 65° C. The reaction mixture was gradually cooled, after which a sodium hydrogencarbonate aqueous solution was added to neutralize the mixture. The precipitated solids were filtered to obtain the title compound (4.1 g, 74%).

1. customdescribed in Manufacturing Example 26-1-1 on an ice bath
2. temperatureThe reaction mixture was gradually cooled
3. filtrationThe precipitated solids were filtered