反应详情

To a mixture of 6-methyl-5-trimethylsilanylethynyl-pyridin-2-ylamine (450 mg, 1.9 mmol) described in Manufacturing Example 187-1-1 and methanol (5 mL) was added potassium carbonate (390 mg, 2.8 mmol), which was stirred for 30 minutes at the same temperature. Water was added to the reaction mixture, which was extracted with ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, and was concentrated under a reduced pressure. The residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1) to obtain the title compound (220 mg, 88%).

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with saturated aqueous sodium chloride
3. concentrationwas concentrated under a reduced pressure
4. customThe residue was purified by silica gel column chromatography (heptane:ethyl acetate=1:1)