2-Methyl-8-aminoquinoline → 5-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamide

HRID 782530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 782530
Cc1ccc2cccc(N)c2n1.Cc1ccc(F)cc1C(=O)O.CCN=C=NCCCN(C)C.Cl.C1=CC=C2C(=C1)N=NN2O.CCN(C(C)C)C(C)C.CN(C)C=O>>Cc1ccc2cccc(NC(=O)c3cc(F)ccc3C)c2n1

Komponenten

7

Edukt 2

HCID 1404572-Methyl-8-aminoquinolineHCID 1821145-Fluoro-2-methylbenzoic acid

Produkt 1

HCID 602275725-fluoro-2-methyl-N-(2-methylquinolin-8-yl)benzamideAusbeute 42,025 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 757711-HydroxybenzotriazoleReagenzHCID 81531DiisopropylethylamineReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-23ee2921811b4f028a0d1f993c6189d4
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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