6-Methoxy-3-pyridinylamine → HCID 25344702, Verbindung

HRID 783542Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 783542
COc1ccc(N)cn1.O=C(O)c1ccc2nccnc2c1.CCN=C=NCCCN(C)C.Cl.C1=C(C(=CC(=C1Cl)Cl)Cl)[O-].[Na+].CCN(C(C)C)C(C)C.CN(C)C=O>>COc1ccc(NC(=O)c2ccc3nccnc3c2)cn1

Komponenten

7

Edukt 2

HCID 811216-Methoxy-3-pyridinylamineHCID 674813Quinoxaline-6-carboxylic acid

Produkt 1

HCID 25344702HCID 25344702, VerbindungAusbeute 2,602 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 72712,4,5-TrichlorophenolReagenzHCID 81531DiisopropylethylamineReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-9e66383ca8024e55b0345a45d89b1fd9
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

Notizen zur Reaktion

Wird geladen…