1,3-Dibromopropane → 3,4,7,8-Tetrahydro-2H,6H-pyrimido[2,1-b][1,3]thiazine

Participants

Reaction Steps

3,4,7,8-Tetrahydro-2H,6H-pyrimido[2,1-b]-[1,3]-thiazine was prepared by the above-described reaction scheme wherein n=2 and m=2. The starting materials were 3,4,5,6-tetrahydro-2-pyrimidinethiol and 1,3-dibromopropane (both obtained from Aldrich Chemical Company, Milwaukee, Wis.), and the remainder of the preparation process was essentially the same as described above. The resulting crude product was 93 percent (%) pure and was used directly for catalysis.

Provenance & Evidence