1,3-Dibromopropane → 3,4,7,8-Tetrahydro-2H,6H-pyrimido[2,1-b][1,3]thiazine

HRID 78387Notes

Reaction equation

HRID 78387 reaction equation
[N:1]1[CH2:6][CH2:5][CH2:4][NH:3][C:2]=1[SH:7].Br[CH2:9][CH2:10][CH2:11]Br>>[S:7]1[CH2:11][CH2:10][CH2:9][N:1]2[CH2:6][CH2:5][CH2:4][N:3]=[C:2]12

Participants

3

Reactant 2

HCID 80011,3-DibromopropaneHCID 178527864HCID 178527864, compound

Product 1

HCID 128266083,4,7,8-Tetrahydro-2H,6H-pyrimido[2,1-b][1,3]thiazine

Procedure

3,4,7,8-Tetrahydro-2H,6H-pyrimido[2,1-b]-[1,3]-thiazine was prepared by the above-described reaction scheme wherein n=2 and m=2. The starting materials were 3,4,5,6-tetrahydro-2-pyrimidinethiol and 1,3-dibromopropane (both obtained from Aldrich Chemical Company, Milwaukee, Wis.), and the remainder of the preparation process was essentially the same as described above. The resulting crude product was 93 percent (%) pure and was used directly for catalysis.

Sources & evidence

ORD record
ord-fb8297e58d284574aa4378b28e489f5c
Source dataset
uspto-grants-2014_09
Patent number
US08841399B2

Reaction notes

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