Thionyl Chloride → 2-Formyl-5-(trifluoromethyl)benzoyl chloride

HRID 78548Notes

Reaction equation

HRID 78548 reaction equation
[CH:1]([C:3]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:4]=1[C:5](O)=[O:6])=[O:2].S(Cl)([Cl:18])=O>>[CH:1]([C:3]1[CH:11]=[CH:10][C:9]([C:12]([F:15])([F:14])[F:13])=[CH:8][C:4]=1[C:5]([Cl:18])=[O:6])=[O:2]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 866408592-Formyl-5-(trifluoromethyl)benzoic acid

Product 1

HCID 871140332-Formyl-5-(trifluoromethyl)benzoyl chloride

Procedure

A solution of Example 375A (0.6 g) and thionyl chloride (3.27 g, 27.5 mmol) was refluxed for 2 hr. The reaction solution was cooled to room temperature, concentrated, azeotroped with toluene, and used without further purification.

Workup

  1. concentrationconcentrated
  2. customazeotroped with toluene
  3. customused without further purification

Sources & evidence

ORD record
ord-3ccb49dfcfe84c628b4d5ddde61629b1
Source dataset
uspto-grants-2014_09
Patent number
US08841334B2

Reaction notes

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