反应详情

In 10 g of xylene were suspended 1.0 g of compound (2a) and 522 mg of phenol, to which 460 μL of SOCl2 was then added dropwise before heating to reflux for 3 hours, followed by further adding 184 μL of SOCl2 and additionally heating to reflux for one hour. The reaction solvent was distilled off, followed by adding methanol to the residue before stirring. The precipitated crystal was collected by filtration to provide 880 mg of phenyl 2-hydroxy-4,5-dimethoxybenzoate (3a) at a yield of 64%.

1. temperaturebefore heating
2. temperatureto reflux for 3 hours
3. temperatureadditionally heating
4. temperatureto reflux for one hour
5. distillationThe reaction solvent was distilled off
6. additionby adding methanol to the residue
7. filtrationThe precipitated crystal was collected by filtration