反应详情

温度

130 °C

In 1 mL of xylene were suspended 200 mg of 2-hydroxy-4,5-dimethoxybenzoic acid 4-nitrophenyl ester and 119 mg of 2-amino-1,3-thiazole-4-carboxylic acid methyl ester in a stream of argon, which was then stirred at 130° C. for 12 hours. The reaction mixture was allowed to stand to cool, to which 1 mL of methanol was then added, followed by heating to reflux for one hour. The resultant reaction mixture was allowed to stand to cool, followed by collecting the precipitated crystal by filtration at 30° C. or lower before drying under reduced pressure to provide 180 mg of the title compound (5a) at a yield of 80%.

1. additionwas then added
2. temperatureby heating
3. temperatureto reflux for one hour
4. customThe resultant reaction mixture
5. temperatureto cool
6. customby collecting the precipitated crystal
7. filtrationby filtration at 30° C.
8. customlower before drying under reduced pressure