Methane → Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

HRID 78750Notes

Reaction equation

HRID 78750 reaction equation
[CH2:1]([O:3][C:4](=[O:12])[C:5]([C:7]1[CH2:11][CH2:10][O:9][CH:8]=1)=[O:6])[CH3:2].C.[CH2:14]([OH:16])[CH3:15]>>[CH2:1]([O:3][C:4](=[O:12])[C:5]([CH:7]1[CH2:11][CH2:10][O:9][CH:8]1[O:16][CH2:14][CH3:15])=[O:6])[CH3:2]

Participants

4

Reactant 3

HCID 297MethaneHCID 702EthanolHCID 11571862HCID 11571862, compound

Product 1

HCID 67607633Ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate

Conditions

Temperature
45 °C

Procedure

Ethyl-2-(4,5-dihydrofuran-3-yl)-2-oxoacetate (10 g) was dissolved in Ethanol (50 ml) and Methane sulphoic acid (0.1 ml) was added to it. The reaction mass was stirred at 40-50° C. for 12 hrs. Reaction mass was concentrated to residue under vacuum. Residue was dissolved in dichloromethane (50 ml) and washed with water (50 ml). Reaction mass was concentrated to residue to get ethyl-2-(2-ethoxytetrahydrofuran-3-yl)-2-oxoacetate (Yield 9.2 g).

Workup

  1. customReaction mass
  2. concentrationwas concentrated to residue under vacuum
  3. dissolutionResidue was dissolved in dichloromethane (50 ml)
  4. washwashed with water (50 ml)
  5. customReaction mass
  6. concentrationwas concentrated to residue

Sources & evidence

ORD record
ord-62a1df65a239421ea94cf65b148ce0c3
Source dataset
uspto-grants-2014_09
Patent number
US08841467B2

Reaction notes

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