Ammonium Acetate → 2-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

HRID 78798Notes

Reaction equation

HRID 78798 reaction equation
[Cl:1][C:2]1[C:3]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5](O)=[O:6].C([O-])(=O)C.[NH4+:24]>>[Cl:1][C:2]1[C:3]([NH:11][C:12]2[CH:17]=[CH:16][C:15]([I:18])=[CH:14][C:13]=2[F:19])=[C:4]([CH:8]=[CH:9][N:10]=1)[C:5]([NH2:24])=[O:6]

Participants

3

Reactant 2

HCID 517165Ammonium AcetateHCID 576496342-Chloro-3-(2-fluoro-4-iodophenylamino)-isonicotinic acid

Product 1

HCID 116682922-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide

Procedure

2-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.2 mmol of 2-Chloro-3-(2-fluoro-4-iodo-phenylamino)-isonicotinic acid and 0.5 mmol of ammonium acetate. LC/MS [8.61 min; 392 (M+1)].

Workup

  1. customLC/MS [8.61 min; 392 (M+1)]

Sources & evidence

ORD record
ord-aada415e2e814b5f95607a40efd762fd
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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