Phenylhydrazine → 3-[(2-fluoro-4-iodophenyl)amino]-N'-phenylisonicotinohydrazide

HRID 78799Notes

Reaction equation

HRID 78799 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[C:19]1([NH:25][NH2:26])[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[F:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([NH:26][NH:25][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:14]

Participants

3

Reactant 2

HCID 7516PhenylhydrazineHCID 590267913-((2-Fluoro-4-iodophenyl)amino)isonicotinic acid2×

Product 1

HCID 115324383-[(2-fluoro-4-iodophenyl)amino]-N'-phenylisonicotinohydrazide

Procedure

3-[(2-fluoro-4-iodophenyl)amino]-N′-phenylisonicotinohydrazide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.45 mmol of 3-[(2-fluoro-4-iodophenyl)amino]isonicotinic acid (intermediate 1) and 0.7 mmol of phenylhydrazine. LC/MS [9.52 min; 449 (M+1)]

Workup

  1. customLC/MS [9.52 min; 449 (M+1)]

Sources & evidence

ORD record
ord-61e7c33bebf24fbbbcd8f07b6d9c952b
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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