Ammonium Acetate → 3-(4-Iodo-phenylamino)-isonicotinamide

HRID 78827Notes

Reaction equation

HRID 78827 reaction equation
[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:17]=[N:16][CH:15]=[CH:14][C:10]=2[C:11](O)=[O:12])=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+:22]>>[I:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9]2[CH:17]=[N:16][CH:15]=[CH:14][C:10]=2[C:11]([NH2:22])=[O:12])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 517165Ammonium AcetateHCID 117098523-(4-Iodophenyl)amino-isonicotinic acid

Product 1

HCID 116314583-(4-Iodo-phenylamino)-isonicotinamide

Procedure

3-(4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.2 mmol of 3-(4-iodophenyl)amino-isonicotinic acid and 0.4 mmol of ammonium acetate. LC/MS [5.03 min; 340 (M+1)]

Workup

  1. customLC/MS [5.03 min; 340 (M+1)]

Sources & evidence

ORD record
ord-e8fd56a9fafa42b1bff580e42c3326c5
Source dataset
uspto-grants-2014_09
Patent number
US08841459B2

Reaction notes

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