反应详情

Aluminum chloride (6.5 g, 48.8 mmol) was added to a stirred mixture of 1-fluoro-2-methoxybenzene (5.0 mL, 44.4 mmol) and hexanoyl chloride (7.5 mL, 53.3 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 45 minutes and then partitioned between EtOAc (100 mL) and water (100 mL). The EtOAc layer was washed with water (100 mL), aqueous K2CO3 (100 mL) and brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-fluoro-4-methoxyphenyl)-1-hexanone (9 g) as a solid.

1. temperatureThe mixture warmed
2. custompartitioned between EtOAc (100 mL) and water (100 mL)
3. washThe EtOAc layer was washed with water (100 mL), aqueous K2CO3 (100 mL) and brine (50 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated under vacuum