反应详情

N-Bromosuccinimide (1.41 g, 7.93 mmol) was added to a solution of 2-butyl-6-fluoro-5-hydroxy-1-indanone (1.76 g, 7.93 mmol) in anhydrous N,N-dimethylformamide (15 mL). The resulting solution was stirred at room temperature for two hours. The solvent was evaporated under vacuum and the residue was partitioned between EtOAc (100 mL) and water (100 ml). The organic phase was washed with water (4×100 mL) and brine (50 mL), dried over MgSO4, filtered, and evaporated under vacuum to provide crude 4-bromo-2-butyl-6-fluoro-5-hydroxy-1-indanone (2.17 g) as an oil.

1. customThe solvent was evaporated under vacuum
2. customthe residue was partitioned between EtOAc (100 mL) and water (100 ml)
3. washThe organic phase was washed with water (4×100 mL) and brine (50 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated under vacuum