反应详情

Aluminum chloride (1.16 g, 8.72 mmol) was added to a stirred mixture of 1-chloro-3-fluoro-2-methoxybenzene (1.00 mL, 8.72 mmol) and hexanoyl chloride (1.47 mL, 10.46 mmol) at room temperature. The mixture warmed and HCl evolution occurred. The resulting mixture was stirred at room temperature for 67 hours and then partitioned between EtOAc (40 mL) and ice cold water (40 mL). The EtOAc layer was washed with brine (30 mL), dried over MgSO4, filtered, and evaporated under vacuum to yield crude 1-(3-chloro-5-fluoro-4-methoxyphenyl)-1-hexanone as an oil.

1. temperatureThe mixture warmed
2. custompartitioned between EtOAc (40 mL) and ice cold water (40 mL)
3. washThe EtOAc layer was washed with brine (30 mL)
4. dry with materialdried over MgSO4
5. filtrationfiltered
6. customevaporated under vacuum