(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol → 4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

HRID 79138ノート

反応式

HRID 79138 の反応式
[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1

参加物

4

反応物 1

HCID 59419388(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol

生成物 1

HCID 594193864-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde収率 82.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

Manganese(IV) oxide, <5 micron, activated (38.1 g, 439 mmol) was added to a solution of compound 223 (16.73 g, 87.8 mmol) in chloroform (800 mL). The reaction was stirred overnight, filtered through Celite, and the filtrate was concentrated in vacuo to yield compound 224 (13.7 g, 82.8% yield). 1H NMR (500 MHz, CDCl3) δ 10.31 (s, 1 H) 8.88 (s, 1 H) 2.65 (s, 2 H) ppm.

後処理

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-8ade62ae47844b1b97a849fa3f1c3b66
出典データセット
uspto-grants-2014_09
特許番号
US08841312B2

反応ノート

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