Trifluoroacetic acid → HCID 58299788, compound

HRID 79218Notes

Reaction equation

HRID 79218 reaction equation
C(O)(C(F)(F)F)=O.[CH:8]1([N:13]2[C:17]3[N:18]=[C:19]([NH2:22])[N:20]=[CH:21][C:16]=3[C:15]3[CH:23]=[CH:24][N:25]=[CH:26][C:14]2=3)[CH2:12][CH2:11][CH2:10][CH2:9]1.Cl[C:28]1[N:33]=[CH:32][C:31]([S:34]([N:37]2[CH2:42][CH2:41][CH:40]([N:43]([CH3:45])[CH3:44])[CH2:39][CH2:38]2)(=[O:36])=[O:35])=[CH:30][CH:29]=1>>[CH:8]1([N:13]2[C:17]3[N:18]=[C:19]([NH:22][C:28]4[CH:29]=[CH:30][C:31]([S:34]([N:37]5[CH2:42][CH2:41][CH:40]([N:43]([CH3:45])[CH3:44])[CH2:39][CH2:38]5)(=[O:35])=[O:36])=[CH:32][N:33]=4)[N:20]=[CH:21][C:16]=3[C:15]3[CH:23]=[CH:24][N:25]=[CH:26][C:14]2=3)[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 434306091-[(6-chloro-3-pyridinyl)sulfonyl]-N,N-dimethyl-4-PiperidinamineHCID 582995859-Cyclopentyl-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Product 1

HCID 58299788HCID 58299788, compound

Procedure

Compound 362 was prepared as an off-white solid (TFA salt) from compound 4 and compound 363 using chemistry similar to that described in example 200. 1H NMR (400 MHz, CD3OD) δ ppm 9.56 (1 H, s), 9.25 (1 H, s), 8.66-8.75 (2 H, m), 8.58 (2 H, s), 8.18 (1 H, dd, J=8.8, 2.5 Hz), 5.50 (1 H, quin, J=8.8 Hz), 4.01 (2 H, d, J=12.5 Hz), 3.22 (1 H, tt, J=12.1, 3.8 Hz), 2.86 (6 H, s), 2.44-2.60 (4 H, m), 2.12-2.35 (6 H, m), 1.74-2.01 (4 H, m). LCMS-ESI (POS), M/Z, M+1: Found 521.2.

Sources & evidence

ORD record
ord-81a2c742f83e479999e0e41773659740
Source dataset
uspto-grants-2014_09
Patent number
US08841312B2

Reaction notes

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