Trifluoroacetic acid → HCID 58299716, compound

Participants

Role	Name	HCID	Charge
Reactant	Trifluoroacetic acid	HCID 6422	—
Reactant	(6-Chloropyridin-3-yl)(4-(dimethylamino)piperidin-1-yl)methanone	HCID 43586003	—
Reactant	9-Cyclopentyl-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine	HCID 58299585	—
Product	HCID 58299716	HCID 58299716	—

Reaction Steps

Compound 364 was prepared as a light yellow solid (TFA salt) from compound 4 and compound 365 using chemistry similar to that described in example 200. 1H NMR (500 MHz, CD3OD) δ ppm 9.57 (1 H, s), 9.27 (1 H, s), 8.56-8.64 (2 H, m), 8.51 (1 H, d, J=1.7 Hz), 8.44 (1 H, d, J=8.8 Hz), 8.02 (1 H, dd, J=8.7, 2.3 Hz), 5.47 (1 H, quin, J=8.9 Hz), 3.49-3.60 (1 H, m, J=12.0, 12.0, 3.8, 3.7 Hz), 2.91 (6 H, s), 2.48-2.61 (2 H, m), 2.02-2.34 (6 H, m), 1.85-1.98 (2 H, m), 1.70-1.85 (2 H, m, J=12.3, 12.3, 12.2, 4.4 Hz). LCMS-ESI (POS), M/Z, M+1: Found 485.2.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08841312B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-4809caaa0258494496cfca62bbba2362
Source note	uspto-grants-2014_09