Trifluoroacetic acid → HCID 58299716, compound

HRID 79219Notes

Reaction equation

HRID 79219 reaction equation
C(O)(C(F)(F)F)=O.[CH:8]1([N:13]2[C:17]3[N:18]=[C:19]([NH2:22])[N:20]=[CH:21][C:16]=3[C:15]3[CH:23]=[CH:24][N:25]=[CH:26][C:14]2=3)[CH2:12][CH2:11][CH2:10][CH2:9]1.Cl[C:28]1[N:33]=[CH:32][C:31]([C:34]([N:36]2[CH2:41][CH2:40][CH:39]([N:42]([CH3:44])[CH3:43])[CH2:38][CH2:37]2)=[O:35])=[CH:30][CH:29]=1>>[CH:8]1([N:13]2[C:17]3[N:18]=[C:19]([NH:22][C:28]4[CH:29]=[CH:30][C:31]([C:34]([N:36]5[CH2:37][CH2:38][CH:39]([N:42]([CH3:44])[CH3:43])[CH2:40][CH2:41]5)=[O:35])=[CH:32][N:33]=4)[N:20]=[CH:21][C:16]=3[C:15]3[CH:23]=[CH:24][N:25]=[CH:26][C:14]2=3)[CH2:9][CH2:10][CH2:11][CH2:12]1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 43586003(6-Chloropyridin-3-yl)(4-(dimethylamino)piperidin-1-yl)methanoneHCID 582995859-Cyclopentyl-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine

Product 1

HCID 58299716HCID 58299716, compound

Procedure

Compound 364 was prepared as a light yellow solid (TFA salt) from compound 4 and compound 365 using chemistry similar to that described in example 200. 1H NMR (500 MHz, CD3OD) δ ppm 9.57 (1 H, s), 9.27 (1 H, s), 8.56-8.64 (2 H, m), 8.51 (1 H, d, J=1.7 Hz), 8.44 (1 H, d, J=8.8 Hz), 8.02 (1 H, dd, J=8.7, 2.3 Hz), 5.47 (1 H, quin, J=8.9 Hz), 3.49-3.60 (1 H, m, J=12.0, 12.0, 3.8, 3.7 Hz), 2.91 (6 H, s), 2.48-2.61 (2 H, m), 2.02-2.34 (6 H, m), 1.85-1.98 (2 H, m), 1.70-1.85 (2 H, m, J=12.3, 12.3, 12.2, 4.4 Hz). LCMS-ESI (POS), M/Z, M+1: Found 485.2.

Sources & evidence

ORD record
ord-4809caaa0258494496cfca62bbba2362
Source dataset
uspto-grants-2014_09
Patent number
US08841312B2

Reaction notes

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