反应详情

温度

85 °C

A mixture of 1-benzyl-3-ethyl-4-nitro-1H-indazole (46.0 mg, 0.164 mmol), iron powder (91.3 mg, 1.64 mmol) and ammonium chloride (4.4 mg, 0.082 mmol) was stirred in a 4:1 mixture of ethanol and water (5 mL) with heating to 85° C. for 60 minutes. The solvent was removed under reduced pressure. Ethyl acetate (4 mL) and triethylamine (1 mL) was added and the mixture was heated for 15 minutes at 85° C. After cooling, the mixture was filtered through glass fiber filter paper, rinsing with methanol, dichloromethane and ethyl acetate. The filtrate was concentrated under reduced pressure to provide 1-benzyl-3-ethyl-1H-indazol-4-amine as an oil (40 mg).

1. customThe solvent was removed under reduced pressure
2. additionEthyl acetate (4 mL) and triethylamine (1 mL) was added
3. temperaturethe mixture was heated for 15 minutes at 85° C
4. temperatureAfter cooling
5. filtrationthe mixture was filtered through glass fiber
6. filtrationfilter paper
7. washrinsing with methanol, dichloromethane and ethyl acetate
8. concentrationThe filtrate was concentrated under reduced pressure