Hydrochloric Acid → 3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridine-7-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

To a solution of ethyl 3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridine-7-carboxylate (430 mg, 0.891 mmol) (Example 23) in THF/water (6 mL/1 mL) was added lithium hydroxide (21.3 mg, 0.89 mmol). The mixture was heated at 70° C. with stirring in a sealed tube for 2 hours. The mixture was allowed to cool and hydrogen chloride (0.45 mL, 4M in dioxane) was added. The solvent was removed under reduced pressure to give a mixture of the product and lithium chloride (410 mg) which was carried on directly to the next step.

Provenance & Evidence