反应详情

温度

70 °C

To a solution of ethyl 3-(3-ethyl-1-((6-methylpyridin-2-yl)methyl)-1H-indazol-4-ylcarbamoyl)imidazo[1,2-a]pyridine-7-carboxylate (430 mg, 0.891 mmol) (Example 23) in THF/water (6 mL/1 mL) was added lithium hydroxide (21.3 mg, 0.89 mmol). The mixture was heated at 70° C. with stirring in a sealed tube for 2 hours. The mixture was allowed to cool and hydrogen chloride (0.45 mL, 4M in dioxane) was added. The solvent was removed under reduced pressure to give a mixture of the product and lithium chloride (410 mg) which was carried on directly to the next step.

1. temperatureto cool
2. customThe solvent was removed under reduced pressure
3. customto give