反应详情

To 1-((6-methoxypyridin-2-yl)methyl)-4-nitro-3-vinyl-1H-indazole (1.89 g, 6.09 mmol) in MeOH (60 mL) was added Pd(OH)2/C (20 wt %, 400 mg). The reaction mixture was purged with N2 and charge with H2 (45 psi). The reaction mixture was recharged H2 to 45 psi after 45 minute. The reaction was stopped after 5 hours. The reaction mixture was filtered through Celite®, washed with MeOH (200 mL) and concentrated to provide the desired product (1.36 g).

1. customThe reaction mixture was purged with N2
2. additioncharge with H2 (45 psi)
3. customafter 45 minute
4. filtrationThe reaction mixture was filtered through Celite®
5. washwashed with MeOH (200 mL)
6. concentrationconcentrated