HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Dichloromethane methanol ammonium hydroxide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67259729 | — |
| Reactant | (3R,4R)-tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)-3-fluoropiperidine-1-carboxylate | HCID 67261845 | — |
| Product | Dichloromethane methanol ammonium hydroxide | HCID 21896990 | — |
| Product | N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide | HCID 67259729 | — |
Reaction Steps
Preparation of (N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide: To (3R,4R)-tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)-3-fluoropiperidine-1-carboxylate (12 mg, 0.02 mmol) in DCM (1 mL) was added TFA (1 mL). The reaction was stirred for one hour and concentrated. Silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) provided the desired product (7 mg). MS (ES+APCI) m/z=514 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08841455B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-b219d40e09d74712a760c2898f6b3d0d |
| Source note | uspto-grants-2014_09 |