HRID79306

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6344

Dichloromethane

CH2Cl2

HCID6422

未命名化合物

结构：CCc1nn(Cc2cccc(O[C@@H]3CCNC[C@H]3F)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12

HCID67259729

未命名化合物

结构：CCc1nn(Cc2cccc(O[C@@H]3CCN(C(=O)OC(C)(C)C)C[C@H]3F)n2)c2cccc(NC(=O)c3cnc4ccccn34)c12

HCID67261845

未命名化合物

PRODUCTS

生成物

HCID21896990

未命名化合物

HCID67259729

未命名化合物

PROCEDURE

实验过程

Preparation of (N-(3-ethyl-1-((6-((3R,4R)-3-fluoropiperidin-4-yloxy)pyridin-2-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide: To (3R,4R)-tert-butyl 4-(6-((3-ethyl-4-(imidazo[1,2-a]pyridine-3-carboxamido)-1H-indazol-1-yl)methyl)pyridin-2-yloxy)-3-fluoropiperidine-1-carboxylate (12 mg, 0.02 mmol) in DCM (1 mL) was added TFA (1 mL). The reaction was stirred for one hour and concentrated. Silica gel chromatography (DCM/MeOH/NH4OH 10:1:0.1) provided the desired product (7 mg). MS (ES+APCI) m/z=514 (M+H).

WORKUP

后处理

concentrationconcentrated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-b219d40e09d74712a760c2898f6b3d0d
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08841455B2
来源说明: uspto-grants-2014_09

反应 SMILES

C(C1C2C(=CC=CC=2N[C:13](C2N3C=CC=CC3=NC=2)=[O:14])N(CC2C=CC=C(O[C@@H]3CCNC[C@H]3F)N=2)[N:4]=1)C.[CH2:39]([C:41]1[C:49]2[C:44](=[CH:45][CH:46]=[CH:47][C:48]=2[NH:50][C:51]([C:53]2[N:57]3[CH:58]=[CH:59][CH:60]=[CH:61][C:56]3=[N:55][CH:54]=2)=[O:52])[N:43]([CH2:62][C:63]2[N:68]=[C:67]([O:69][C@@H:70]3[CH2:75][CH2:74][N:73](C(OC(C)(C)C)=O)[CH2:72][C@H:71]3[F:83])[CH:66]=[CH:65][CH:64]=2)[N:42]=1)[CH3:40].C(O)(C(F)(F)F)=O.[CH2:91]([Cl:93])[Cl:92]>>[CH2:91]([Cl:93])[Cl:92].[CH3:13][OH:14].[NH4+:4].[OH-:52].[CH2:39]([C:41]1[C:49]2[C:44](=[CH:45][CH:46]=[CH:47][C:48]=2[NH:50][C:51]([C:53]2[N:57]3[CH:58]=[CH:59][CH:60]=[CH:61][C:56]3=[N:55][CH:54]=2)=[O:52])[N:43]([CH2:62][C:63]2[CH:64]=[CH:65][CH:66]=[C:67]([O:69][C@@H:70]3[CH2:75][CH2:74][NH:73][CH2:72][C@H:71]3[F:83])[N:68]=2)[N:42]=1)[CH3:40]