Thionyl Chloride → HCID 67259700, compound

HRID 79310Notes

Reaction equation

HRID 79310 reaction equation
[CH3:1][O:2][C:3]1[CH:16]=[CH:15][C:6]([CH2:7][N:8]2[CH:12]=[C:11]([CH2:13]O)[CH:10]=[N:9]2)=[CH:5][CH:4]=1.S(Cl)([Cl:19])=O>C(Cl)Cl>[Cl:19][CH2:13][C:11]1[CH:10]=[N:9][N:8]([CH2:7][C:6]2[CH:15]=[CH:16][C:3]([O:2][CH3:1])=[CH:4][CH:5]=2)[CH:12]=1

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 67261360(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methanol

Product 1

HCID 67259700HCID 67259700, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To (1-(4-methoxybenzyl)-1H-pyrazol-4-yl)methanol (5.01 g, 23.0 mmol) in DCM (20 mL) was added thionyl chloride (8 mL). The reaction mixture was stirred for 3 hours and concentrated to provide the desired product (6.37 g).

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-3f8ce13770604662b1e3d6658b643f92
Source dataset
uspto-grants-2014_09
Patent number
US08841455B2

Reaction notes

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