N-(1-((1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-4-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide → N-(3-ethyl-1-((1-(2-hydroxyethyl)-1H-pyrazol-4-yl)methyl)-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide

Participants

Reaction Steps

To N-(1-((1-(2-(tert-butyldimethylsilyloxy)ethyl)-1H-pyrazol-4-yl)methyl)-3-ethyl-1H-indazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide (15 mg, 0.028 mmol) in MeOH (2 mL) was added concentrated hydrochloric acid (5 drops). The reaction was stirred for 3 hours and concentrated. Silica gel chromatography (DCM/MeOH 10:1) gave the desired product (8 mg). MS (ES+APCI) m/z=430 (M+H).

Provenance & Evidence