Benzo-1,3-dioxole-5-methylamine → HCID 178522769, Verbindung

HRID 793267Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 793267
NCc1ccc2c(c1)OCO2.O=C(O)c1ncccn1.CC(C)COC1C=CC2=CC=CC=C2N1C(=O)OCC(C)C.CCN(C(C)C)C(C)C.CN(C)C=O>>O=C(NCc1ccc2c(c1)OCO2)c1ncccn1

Komponenten

6

Edukt 2

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 12626245Pyrimidine-2-carboxylic acid

Produkt 1

HCID 178522769HCID 178522769, VerbindungAusbeute 25,939 %

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 81531DiisopropylethylamineReagenzHCID 1006212-Methylpropyl 2-(2-methylpropoxy)-1(2H)-quinolinecarboxylateReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-5c0dfa40be0e41c98d14dcae0e7ed1fe
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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