反应详情

温度

0 °C

To ethyl 1-(4-methoxybenzyl)-1H-pyrazole-5-carboxylate (1.81 g, 6.95 mmol) in THF (20 mL) at 0° C. was added lithium aluminum hydride (0.317 g, 8.34 mmol). The cold bath was removed. The reaction mixture was stirred for 5 hours, diluted with Et2O (50 mL) and Celite (5 g) was added to the reaction mixture. The mixture was cooled to 0° C. and sodium sulfate decahydrate was cautiously added to quench the reaction. The mixture was filtered and washed with EtOAc (100 mL). The solution was concentrated under reduced pressure to give the product (1.36 g).

1. customThe cold bath was removed
2. additiondiluted with Et2O (50 mL) and Celite (5 g)
3. additionwas added to the reaction mixture
4. additionsodium sulfate decahydrate was cautiously added
5. customto quench
6. customthe reaction
7. filtrationThe mixture was filtered
8. washwashed with EtOAc (100 mL)
9. concentrationThe solution was concentrated under reduced pressure