反应详情

A mixture of 3-ethyl-1-((2-methoxy-6-methylpyridin-3-yl)methyl)-4-nitro-1H-indazole (186 mg, 0.57 mmol), iron powder (318 mg, 5.7 mmol) and NH4Cl (15.2 mg, 0.285 mmol) in EtOH/water (3 mL/0.75 mL) was heated to reflux for 60 minutes. The reaction mixture was filtered through GF/F paper and concentrated to a residue under reduced pressure. Preparative thin layer chromatography eluting with 2% MeOH 0.25% NH4OH in DCM provided the product (108 mg).

1. temperaturewas heated
2. temperatureto reflux for 60 minutes
3. filtrationThe reaction mixture was filtered through GF/F paper
4. concentrationconcentrated to a residue under reduced pressure
5. washPreparative thin layer chromatography eluting with 2% MeOH 0.25% NH4OH in DCM