4-carboxy-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-one → 4-hydroxymethyl-2-isobutyl-6-(4-methyl-phenyl)-2H-pyridazin-3-one

HRID 7940Notes

Reaction equation

HRID 7940 reaction equation
FC1C=C(C2C(C)=C(O)C(=O)N(CC(C)C)N=2)C=CC=1C.[C:22]([C:25]1[C:26](=[O:42])[N:27]([CH2:38][CH:39]([CH3:41])[CH3:40])[N:28]=[C:29]([C:31]2[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=2)[CH:30]=1)(O)=[O:23]>>[OH:23][CH2:22][C:25]1[C:26](=[O:42])[N:27]([CH2:38][CH:39]([CH3:40])[CH3:41])[N:28]=[C:29]([C:31]2[CH:36]=[CH:35][C:34]([CH3:37])=[CH:33][CH:32]=2)[CH:30]=1

Participants

3

Reactant 2

HCID 219916354-carboxy-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-oneHCID 178419042HCID 178419042, compound

Product 1

HCID 219916444-hydroxymethyl-2-isobutyl-6-(4-methyl-phenyl)-2H-pyridazin-3-one

Procedure

Following the procedure of Example 1 (8), 4-carboxy-2-isobutyl-6-(4-methylphenyl)-2H-pyridazin-3-one was reacted to yield the title compound as slightly yellow needles (yield: 46.0%).

Workup

  1. customwas reacted

Sources & evidence

ORD record
ord-c276e1f8025c489e94c3d89be8644b2f
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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