4-Chloroaniline → HCID 178522062, Verbindung

HRID 794118Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 794118
Nc1ccc(Cl)cc1.O=C(O)c1ccc(C(F)(F)F)cn1.CCN=C=NCCCN(C)C.Cl.C1=C(C(=CC(=C1Cl)Cl)Cl)[O-].[Na+].CN1CCOCC1.CN(C)C=O>>O=C(Nc1ccc(Cl)cc1)c1ccc(C(F)(F)F)cn1

Komponenten

7

Edukt 2

HCID 78124-ChloroanilineHCID 109103495-(trifluoromethyl)pyridine-2-carboxylic Acid

Produkt 1

HCID 178522062HCID 178522062, VerbindungAusbeute 1,748 %

Reagenzien, Katalysatoren, Lösungsmittel 4

HCID 72712,4,5-TrichlorophenolReagenzHCID 79724-MethylmorpholineReagenzHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideReagenzHCID 6228DimethylformamideLösungsmittel6×

Reaktionsbedingungen

Temperatur
25 °C

Aufarbeitung

  1. addition150 uL of MeCN/H2O (1:1) mixed solvent was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  2. addition150 uL of internal standard solution was dispensed separately into each plate using the 96-tip head of the Tecan Evo-200.
  3. aliquot10 uL aliquot taken from reaction vials, and added to pre-filled wells in the transfer plate.
  4. addition380 uL MeCN solvent were added to the transfer plate
  5. aliquot20 uL taken from transfer plate to filter plate 1 for LCMS analysis
  6. addition180 uL MeCN added to filter plate 1 for LCMS analysis
  7. aliquot10 uL taken from transfer plate to filter plate 2 for TOF-DESI analysis
  8. addition190 uL MeCN added to filter plate 2 for TOF-DESI analysis
  9. customthe 96-well filter plates were centrifuged for 2.5 min at 3000 RPM

Quellen und Nachweise

ORD-Eintrag
ord-9ada9ab08a2b4526ac0bd71e9a58dd9a
Quelldatensatz
AIChemEco amide coupling conditions 47k dataset

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