Methylamine → 2-isobutyl-4-methylaminomethyl-6-(4-methylphenyl)-2H-pyridazin-3-one

HRID 7945Notes

Reaction equation

HRID 7945 reaction equation
[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12]OS(C)(=O)=O)=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3].[CH3:25][NH2:26]>>[CH2:1]([N:5]1[C:10](=[O:11])[C:9]([CH2:12][NH:26][CH3:25])=[CH:8][C:7]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)=[N:6]1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 219915892-isobutyl-4-methanesulfonyloxymethyl-6-(4-methylphenyl)-2H-pyridazin-3-one2×

Product 1

HCID 219916492-isobutyl-4-methylaminomethyl-6-(4-methylphenyl)-2H-pyridazin-3-one

Procedure

Following the procedure of Example 9 (4), 2-isobutyl-4-methanesulfonyloxymethyl-6-(4-methylphenyl)-2H-pyridazin-3-one and methylamine were reacted to yield the title compound as a slightly yellow oil (yield: 94.5%).

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-c911fd7775ee4fb784d12a182bdc5b96
Source dataset
uspto-grants-2006_08
Patent number
US07087606B2

Reaction notes

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